While Erik ten Hag's squad has made significant strides in the Premier League in recent weeks, they suffered a defeat in their first European match of the season, so increasing the pressure.
A voyage to Transnistria appears to be arduous, but Sheriff has a history of pulling off impressive outcomes, as evidenced by their Champions League victory over Real Madrid in the previous season.
Losing this game will put United in a precarious position in the group stage, which would undoubtedly be viewed as a major letdown.
Date and time of the Sheriff vs. Manchester United match
Manchester United versus Sheriff
Date: September 15, 2022
Kick-off: 5:45pm BST / 12:45pm ET / 10:15pm IST
Stream: Twistok.com (FREE)
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Sheriff Squad and Team Updates
The Sheriff squad has no new injury concerns, but goalkeeper Dumitru Celeadnic is ineligible after testing positive for Covid-19.
Stjepan Tomas is likely to reassign Mouhamed Diop and Moussa Kyabou to the midfield following the weekend's victory over Mislami Orhei. Iyayi Atiemwen, who scored off the bench against Omonia, is expected to start over Steve Ambri.
Sheriff possible XI: Koval; Zohouri, Kiki, Radeljic, Kpozo; Badolo, Kyabou, Diop; Ouattara, Atiemwen, Akanbi
Manchester United personnel and team updates
Since his Achilles injury, Ten Hag revealed that Anthony Martial has not returned to training. The absences of Facundo Pellistri and Brandon Williams may afford Donny van de Beek a chance to play if he has fully recovered from his knock.
Donny van de Beek Getty Manchester United 2022-23
The Premier League bye week has allowed Lisandro Martinez, Raphael Varane, and Bruno Fernandes to regain full fitness and return to the starting lineup.
Luke Shaw is still questionable due to a foot injury, but Marcus Rashford should start up front after being benched against Sociedad.
De Gea; Dalot; Martinez; Malacia; Eriksen; McTominay; Antony; Fernandes; Sancho; Rashford.
Oladimeji Shoyoye 2 w
Interesting